The Science

Senetek PLC forever changed skin rejuvenation science with the innovative use of cytokinins like Kinetin and Zeatin in therapeutic skin care applications. Cytokinins are a class of plant growth factors which have been widely studied for their activity in plants and are well known for delaying senescence (aging) of leaves. For over a decade, Senetek PLC has fostered scientific research internationally for their similar beneficial effect on human skin cells.

Physicians quickly embraced the development of cytokinin-based products as revolutionary a decade ago because clinical studies showed efficacy similar to or better than prescription Renova®1 without the associated side effects such as drying, redness, burning and peeling. Cytokinins make a genuine difference in reversing the signs of aging with virtually no side effects.2

Now, Senetek PLC is driving cytokinin-based skin care technology to even greater levels of effectiveness with a second generation of cytokinins. Pyratine-6™ combines the safety profile of its predecessors, Kinetin and Zeatin, with unprecedented rapid delivery of benefits to significantly improve the visible signs of aging skin.

Pyratine-6™ is a cytokinin innovation fusing a tetrahydropyranyl molecule group with the Kinetin structure producing greater molecular weight and significantly more activity in vitro.2 Pyratine-6™ also showed more rapid onset of action in human clinical trials3 and significantly greater improvement compared to its predecessors, Kinetin and Zeatin.

Studies show cytokinin activity greatly benefits skin:
 

  • Delays the destruction of the fibroblast2
    Cytokinins keep fibroblasts healthy and active so they continue to produce more collagen and elastin
     

  • Significantly increases mitochondrial activity2
    Cytokinins’ increase in production of cellular bioenergy ensures skin’s vitality
     

  • Demonstrates antioxidant /anti-ROS activity2
    Cytokinins remove harmful free radicals that may be contributing to the visible signs of aging
     

  • Prevents reversion of actin patterns2
    Cytokinins help maintain cell structure and integrity
     

  • Delays the senescence of cells by removing cellular debris2
    Cytokinins help remove age-dependent cellular debris, a characteristic of aging cells and difficult to remove


Rapid-acting cytokinin Pyratine-6™ delivers even more:
 

  • Rapid onset of action — results seen in just 2 weeks3
    Pyratine-6™ outperforms first generation cytokinins with a significant reduction in facial redness and roughness within days
     


baseline		  
week 2
 

 

Results of a 12-week clinical trial demonstrated the cosmetic efficacy
of Pyratine-6™ and statistically significant improvements were reported3
 

 

Dr. Jerry McCullough, lead investigator in
the clinical study of Pyratine-6™ stated:

“In addition to the encouraging results in the treatment of photodamaged skin overall, another important finding is the significant reduction in erythema at 2 weeks and the additional reductions at weeks 4, 8, and 12. To my knowledge, this is the first report to show reduced erythema associated with use of a topical non-prescription therapeutic product.”

 

1 Renova® is a registered trademark of OrthoNeutrogena, a division of Ortho-McNeil Pharmaceuticals, Inc.
2 Data on file, Senetek PLC
3 McCullough JL, Garcia RL, Reece B. A clinical Study of Topical Pyratine-6 for Improving the Appearance of Photodamaged Skin. Journal of Drugs in Dermatology. 2008;2:131-135

  


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